HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86624067, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| Reactant | HCID 86624068 | HCID 86624068 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 86624067 | HCID 86624067 | 72.1% |
Reaction Steps
Compound 84 produced in Example 77 (0.85 g, 1.7 mmol), tert-butyl 4-aminopiperidin-1-carboxylate (0.34 g, 1.7 mmol) and triethylamine (0.28 mL, 2.0 mmol) were dissolved in isopropyl alcohol and heated to reflux for 20 hours. After the solvent was evaporated therefrom in vacuo, the residue was purified by a column chromatography (toluene:acetone=4:1) to give Compound 85 (0.74 g, 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07939552B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-9173816638b4415799ec267329b8b369 |
| Source note | uspto-grants-2011_05 |