Sodium Hydroxide → HCID 15942362, compound

Participants

Reaction Steps

Compound (79) (75 mg) was dissolved in THF (1 ml) and 2M NaOH (aq, 1 ml) added. The reaction was stirred at room temperature for 2 h. THF was removed under a stream of N2 and the aqueous layer (˜1 ml) was purified by preparative HPLC to yield compound (80). LCMS purity 99%, m/z 471 [M++H]+, 1H NMR (400 MHz, MeOD), δ: 1.20-1.35 (4H, m, 2×CH2), 1.45-1.65 (4H, m, 2×CH2), 2.00 (2H, t, CH2), 2.25 (2 H, t, CH2), 4.20 (2H, s CH2NH), 5.25 (1H, s CHPh), 6.90 (1H, d, Ar), 7.10 (1H, t, Ar), 7.15-7.40 (7H, m, Ar).

Provenance & Evidence