Sodium Hydroxide → HCID 15940506, compound

Participants

Reaction Steps

Compound (94) (100 mg, 0.18 mmol) was dissolved in THF (1 ml) and 2M NaOH (1 ml) added. The reaction vial was shaken for 4 h before THF removal via a stream of nitrogen. The aqueous residue was purified by preparative HPLC to yield compound (95) (62 mg). LCMS purity 95%, m/z 486 [M++H]+, 1H NMR (400 MHz, MeOD), δ: 1.35 (4H, m, 2×CH2), 1.55-1.75 (4H, m, alkyl), 2.10 (2H, t, CH2), 2.35 (2H, t, CH2), 2.95 (2H, dd, CH), 3.20 (1H, dd, CH), 4.45 (1H, dd, NHCHCO), 5.00 (2H, s, CH2), 7.05 (1H, d, Ar), 7.20-7.35 (6H, m, Ar), 7.55 (2H, m, Ar).

Provenance & Evidence