HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2,5-Anhydro-6-azido-1,3,6-trideoxy-D-ribo-hexitol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 2,5-Anhydro-1,3-dideoxy-D-ribo-hexitol 6-(4-Methylbenzenesulfonate) | HCID 86750355 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2,5-Anhydro-6-azido-1,3,6-trideoxy-D-ribo-hexitol | HCID 86750354 | 77.4% |
Reaction Steps
A mixture, under argon, of 0.560 g of product from Example 337, 2 ml of N,N-dimethylformamide and 0.250 g of sodium azide is stirred at 75° C. for 12 hours. The reaction mixture is diluted with diethyl ether, washed with water and saturated sodium chloride, dried and concentrated in vacuo to give 0.238 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05623081 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-65cba0136c614283a20f8a7670d3a412 |
| Source note | uspto-grants-1997_04 |