反应详情

To a solution of 5-[2-(isopropyloxycarbonylamino)ethylthio]imidazo[1,2-a]pyridine (279 mg, 1 mmole) in chloroform (5 ml) was added N-bromosuccinimide (187 ml, 1.05 mmoles) and the mixture was stirred at room temperature for 1 hour. The reaction solution was washed with water and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography (eluent: ethyl acetate) to obtain 296 mg of the desired product (82.7%, colorless solid).

1. washThe reaction solution was washed with water
2. dry with materialdried over anhydrous magnesium sulfate
3. distillationAfter the solvent was distilled off
4. customthe residue was purified by column chromatography (eluent: ethyl acetate)