Phosphorus oxychloride → 4,5,5,5-Tetrafluoro-4-(trifluoromethyl)-1-pentene

Participants

Reaction Steps

According to another embodiment, the reducing agent can include POCl3, pyridine, and/or a mixture of POCl3 and pyridine. For example, the RF-intermediate 4,5,5,5-tetrafluoro-4-(trifluoromethyl)-2-iodopentan-1-ol can be reacted to form the RF-intermediate 4,5,5,5-tetrafluoro-4-(trifluoromethyl)pent-1-ene in the presence of a mixture of POCl3 and pyridine. This reaction can be performed while maintaining the temperature of the mixture between from about 0° C. to about 5° C., for example.

Provenance & Evidence