HCID 71349, compound → HCID 131728838, compound

HRID 548542Notes

Reaction equation

HRID 548542 reaction equation
[CH3:1][CH:2]([CH2:4][C@H:5]([NH:31][C:32]([C@H:34]([NH:45][C:46]([C@@H:48]([NH:57][C:58]([C@@H:60]([NH:63][C:64]([C@@H:66]([NH:77][C:78]([C@@H:80]([NH:87][C:88]([C@H:90]1[NH:95][C:93](=[O:94])[CH2:92][CH2:91]1)=[O:89])[CH2:81][C:82]1[NH:86][CH:85]=[N:84][CH:83]=1)=[O:79])[CH2:67][C:68]1[C:76]2[C:71](=[CH:72][CH:73]=[CH:74][CH:75]=2)[NH:70][CH:69]=1)=[O:65])[CH2:61][OH:62])=[O:59])[CH2:49][C:50]1[CH:55]=[CH:54][C:53]([OH:56])=[CH:52][CH:51]=1)=[O:47])[CH2:35][C:36]1[C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[NH:38][CH:37]=1)=[O:33])[C:6]([NH:8][C@H:9]([C:17]([N:19]1[C@H:23]([C:24]([NH:26][CH2:27][C:28]([NH2:30])=[O:29])=[O:25])[CH2:22][CH2:21][CH2:20]1)=[O:18])[CH2:10][CH2:11][CH2:12][N:13]=[C:14]([NH2:16])[NH2:15])=[O:7])[CH3:3].C([O-])(=O)C.[CH3:100][CH:101]([CH:103]1[NH:127][C:125](=[O:126])[CH:124]([CH2:128][CH2:129][CH2:130][CH2:131][NH2:132])[NH:123][C:121](=[O:122])[CH:120]([CH2:133][C:134]2[C:142]3[C:137](=[CH:138][CH:139]=[CH:140][CH:141]=3)[NH:136][CH:135]=2)[NH:119][C:117](=[O:118])[CH:116]([CH2:143][C:144]2[CH:149]=[CH:148][C:147]([OH:150])=[CH:146][CH:145]=2)[NH:115][C:113](=[O:114])[CH:112]([NH:151][C:152]([CH:154]([NH2:166])[CH2:155][C:156]2[CH:165]=[CH:164][C:163]3[C:158](=[CH:159][CH:160]=[CH:161][CH:162]=3)[CH:157]=2)=[O:153])[CH2:111][S:110][S:109][CH2:108][CH:107]([C:167]([NH:169][CH:170]([C:174]([NH2:176])=[O:175])[CH:171]([OH:173])[CH3:172])=[O:168])[NH:106][C:104]1=[O:105])[CH3:102]>O>[CH3:102][CH:101]([CH:103]1[NH:127][C:125](=[O:126])[CH:124]([CH2:128][CH2:129][CH2:130][CH2:131][NH2:132])[NH:123][C:121](=[O:122])[CH:120]([CH2:133][C:134]2[C:142]3[C:137](=[CH:138][CH:139]=[CH:140][CH:141]=3)[NH:136][CH:135]=2)[NH:119][C:117](=[O:118])[CH:116]([CH2:143][C:144]2[CH:145]=[CH:146][C:147]([OH:150])=[CH:148][CH:149]=2)[NH:115][C:113](=[O:114])[CH:112]([NH:151][C:152]([CH:154]([NH2:166])[CH2:155][C:156]2[CH:165]=[CH:164][C:163]3[C:158](=[CH:159][CH:160]=[CH:161][CH:162]=3)[CH:157]=2)=[O:153])[CH2:111][S:110][S:109][CH2:108][CH:107]([C:167]([NH:169][CH:170]([C:174]([NH2:176])=[O:175])[CH:171]([OH:173])[CH3:172])=[O:168])[NH:106][C:104]1=[O:105])[CH3:100].[CH3:3][CH:2]([CH2:4][C@H:5]([NH:31][C:32]([C@H:34]([NH:45][C:46]([C@@H:48]([NH:57][C:58]([C@@H:60]([NH:63][C:64]([C@@H:66]([NH:77][C:78]([C@@H:80]([NH:87][C:88]([C@H:90]1[NH:95][C:93](=[O:94])[CH2:92][CH2:91]1)=[O:89])[CH2:81][C:82]1[NH:86][CH:85]=[N:84][CH:83]=1)=[O:79])[CH2:67][C:68]1[C:76]2[C:71](=[CH:72][CH:73]=[CH:74][CH:75]=2)[NH:70][CH:69]=1)=[O:65])[CH2:61][OH:62])=[O:59])[CH2:49][C:50]1[CH:51]=[CH:52][C:53]([OH:56])=[CH:54][CH:55]=1)=[O:47])[CH2:35][C:36]1[C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[NH:38][CH:37]=1)=[O:33])[C:6]([NH:8][C@H:9]([C:17]([N:19]1[C@H:23]([C:24]([NH:26][CH2:27][C:28]([NH2:30])=[O:29])=[O:25])[CH2:22][CH2:21][CH2:20]1)=[O:18])[CH2:10][CH2:11][CH2:12][N:13]=[C:14]([NH2:15])[NH2:16])=[O:7])[CH3:1]

Participants

4

Reactant 2

HCID 71349HCID 71349, compoundHCID 86609520HCID 86609520, compound

Product 1

HCID 131728838HCID 131728838, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

87.5 mg of DECAPEPTYL-acetate was dissolved in 2.6 ml water and placed in a first 5 ml syringe. 1.0 g of SOMATULINE was placed in a second 5 ml syringe and the second syringe placed under vacuum. The two syringes were connected via a valve and Millipore filter, the valve was opened, and the DECAPEPTYL solution allowed to flow into the evacuated SOMATULINE syringe. 10 transfers of the resultant solution was made between the two syringes via alternate depression of their respective plungers producing a homogeneous, semi-solid mixture.

Workup

  1. customplaced in a first 5 ml syringe
  2. customThe two syringes were connected via a valve
  3. filtrationMillipore filter
  4. customproducing a homogeneous, semi-solid mixture

Sources & evidence

ORD record
ord-ebdbf2e2571748f8a4f2f303598d6ae3
Source dataset
uspto-grants-2011_05
Patent number
US07943575B2

Reaction notes

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