Cabergoline → HCID 131728839, compound

HRID 548543Notes

Reaction equation

HRID 548543 reaction equation
[CH3:1][CH:2]([CH:4]1[NH:28][C:26](=[O:27])[CH:25]([CH2:29][CH2:30][CH2:31][CH2:32][NH2:33])[NH:24][C:22](=[O:23])[CH:21]([CH2:34][C:35]2[C:43]3[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=3)[NH:37][CH:36]=2)[NH:20][C:18](=[O:19])[CH:17]([CH2:44][C:45]2[CH:50]=[CH:49][C:48]([OH:51])=[CH:47][CH:46]=2)[NH:16][C:14](=[O:15])[CH:13]([NH:52][C:53]([CH:55]([NH2:67])[CH2:56][C:57]2[CH:66]=[CH:65][C:64]3[C:59](=[CH:60][CH:61]=[CH:62][CH:63]=3)[CH:58]=2)=[O:54])[CH2:12][S:11][S:10][CH2:9][CH:8]([C:68]([NH:70][CH:71]([C:75]([NH2:77])=[O:76])[CH:72]([OH:74])[CH3:73])=[O:69])[NH:7][C:5]1=[O:6])[CH3:3].[CH3:78][CH2:79][NH:80][C:81]([N:83]([C:90]([C@H:92]1[CH2:107][N:106]([CH2:108][CH:109]=[CH2:110])[C@H:105]2[C@@H:94]([C:95]3[C:100]4[C:101]([CH2:104]2)=[CH:102][NH:103][C:99]=4[CH:98]=[CH:97][CH:96]=3)[CH2:93]1)=[O:91])[CH2:84][CH2:85][CH2:86][N:87]([CH3:89])[CH3:88])=[O:82]>O>[CH3:3][CH:2]([CH:4]1[NH:28][C:26](=[O:27])[CH:25]([CH2:29][CH2:30][CH2:31][CH2:32][NH2:33])[NH:24][C:22](=[O:23])[CH:21]([CH2:34][C:35]2[C:43]3[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=3)[NH:37][CH:36]=2)[NH:20][C:18](=[O:19])[CH:17]([CH2:44][C:45]2[CH:46]=[CH:47][C:48]([OH:51])=[CH:49][CH:50]=2)[NH:16][C:14](=[O:15])[CH:13]([NH:52][C:53]([CH:55]([NH2:67])[CH2:56][C:57]2[CH:66]=[CH:65][C:64]3[C:59](=[CH:60][CH:61]=[CH:62][CH:63]=3)[CH:58]=2)=[O:54])[CH2:12][S:11][S:10][CH2:9][CH:8]([C:68]([NH:70][CH:71]([C:75]([NH2:77])=[O:76])[CH:72]([OH:74])[CH3:73])=[O:69])[NH:7][C:5]1=[O:6])[CH3:1].[CH3:78][CH2:79][NH:80][C:81]([N:83]([C:90]([C@H:92]1[CH2:107][N:106]([CH2:108][CH:109]=[CH2:110])[C@H:105]2[C@@H:94]([C:95]3[C:100]4[C:101]([CH2:104]2)=[CH:102][NH:103][C:99]=4[CH:98]=[CH:97][CH:96]=3)[CH2:93]1)=[O:91])[CH2:84][CH2:85][CH2:86][N:87]([CH3:89])[CH3:88])=[O:82]

Participants

4

Reactant 2

HCID 54746CabergolineHCID 71349HCID 71349, compound

Product 1

HCID 131728839HCID 131728839, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

1.0 g. SOMATULINE and 0.1 g CABERGOLINE are added to a 5.0 ml syringe. The two powders are dry-mixed wit a spatula and put under vacuum, e.g., using a vacuum pump. The mixed powder is connected via a valve to another 5 ml syringe containing 2.6 ml water. The valve is opened and the water is mixed with powder through the valve. 10 transfers of the resultant solution are made between the two syringes via alternate depression of their respective plungers to produce a homogeneous, semi-solid mixture. The semisolid is then loaded into 0.3 ml insulin syringes at doses of 0.225 ml.

Workup

  1. additionThe two powders are dry-mixed wit a spatula
  2. customThe mixed powder is connected via a valve to another 5 ml syringe
  3. customto produce a homogeneous, semi-solid mixture

Sources & evidence

ORD record
ord-edba38ff604341148e660e59a9453971
Source dataset
uspto-grants-2011_05
Patent number
US07943575B2

Reaction notes

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