HCID 15524951, compound → HCID 67157886, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1,3-dibromo-5-phenylethynyl-benzene (0.1 g, 0.3 mmol, intermediate 3), (4-prop-2-ynyloxy-phenoxy)-acetic acid methyl ester (66 mg, 0.3 mmol), Pd(PPh3)2Cl2 (10 mg, 0.015 mmol), CuI (16 mg, 0.008 mmol) in dry DMF (1.5 ml) and triethylamine (1.5 ml) was heated in a microwave own for 10 min at 70° C. in a sealed tube. The reaction mixture was filtered through Decalite and the filtrate was evaporated. The residue was purified on column chromatography to give {4-[3-(3-bromo-5-phenylethynyl-phenyl)-prop-2-ynyloxy]-phenoxy}-acetic acid methyl ester in 27 mg (20%) yield.

Provenance & Evidence