Hydrochloric Acid → HCID 57581229, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of {4-[3-(3-bromo-5-phenylethynyl-phenyl)-prop-2-ynyloxy]-phenoxy}-acetic acid methyl ester (66 mg, 0.14 mmol) in THF (1.5 ml) and methanol (0.3 ml) was added a ice-cold solution of LiOH (1 M, 2 ml). The reaction mixture was stirred at 0° C. for 45 min., after which water (10 ml) and aqueous HCl (1M, 2 ml) were added. The mixture was extracted with ethyl acetate (2×5 ml), and the combined organic phases were dried and evaporated to give the title compound in 64 mg (100%) yield.

Provenance & Evidence