Phenylacetylene → HCID 67158074, compound

Participants

Reaction Steps

A solution of phenylacetylene (0.20 g, 1.98 mmol), {4-[3-(3,5-dibromo-phenyl)-prop-2-ynyloxy]-phenoxy}-acetic acid methyl ester (0.3 g, 0.66 mmol), Pd(PPh3)4 (0.11 g, 0.1 mmol) and CuI (0.05 g, 0.26 mmol) in triethylamine (10 ml) was heated in a sealed tube in a microwave own at 65° C. for 1 hour. The reaction mixture was filtered and the filtrate was evaporated. The residue was purified on HPLC using acetonitril/water as eluent to give {4-[3-(3,5-bis-phenylethynyl-phenyl)-prop-2-ynyloxy]-phenoxy}-acetic acid methyl ester in 150 mg (46%) yield.

Provenance & Evidence