Hydrochloric Acid → HCID 57581231, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of {4-[3-(3,5-bis-phenylethynyl-phenyl)-prop-2-ynyloxy]-phenoxy}-acetic acid methyl ester (0.26 g, 0.51 mmol) in THF (5.6 ml) and methanol (1.1 ml) was added a ice-cold solution of LiOH (1 M, 5.6 ml). The reaction mixture was stirred at 0° C. for 45 min., after which water (37 ml) and aqueous HCl (1M, 7.5 ml) were added. The mixture was extracted with ethyl acetate (2×25 ml), and the combined organic phases were dried and evaporated to give the title compound in 240 mg (96%) yield.

Provenance & Evidence