反应详情

A solution of (4-{3-[3-bromo-5-(3-morpholin-4-yl-prop-1-ynyl)-phenyl]-prop-2-ynyloxy}-2-methyl-phenoxy)-acetic acid methyl ester (45 mg, 0.088 mmol) in ethanol (5 ml) and 1N NaOH (0.5 ml) was stirred at 75° C. for 30 min. The reaction mixture was evaporated and the residue dissolved in water (2 ml). Aqueous 1N HCl (0.6 ml) was added and the mixture was extracted with methylene chloride (3×15 ml). The combined organic phases were dried and evaporated to give the title compound in 44 mg (99%) yield.

1. customThe reaction mixture was evaporated
2. dissolutionthe residue dissolved in water (2 ml)
3. additionAqueous 1N HCl (0.6 ml) was added
4. extractionthe mixture was extracted with methylene chloride (3×15 ml)
5. customThe combined organic phases were dried
6. customevaporated