HCID 58378151, compound → HCID 58378166, compound

Participants

Reaction Steps

To a solution of 7-(4-methoxybenzyl)-3-(2-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine (Step F, 25 mg) in methanol, at 0° C. and under a nitrogen atmosphere was added palladium hydroxide on carbon (15 mg, 20 wt % Pd-Degussa type, E101) and the contents hydrogenated at 40 psi for 14 hours. The reaction mixture was filtered and the filter cake washed with methanol (2×10 mL). The filtrate was concentrated under reduced pressure and azeotroped with dichloromethane (2×20 mL) and ethyl acetate (2×20 mL). The oil that is obtained g (20 mgs) was used as such for the subsequent step without further purification.

Provenance & Evidence