Piperidine → HCID 57550252, compound

Participants

Reaction Steps

A mixture of [(2S)-4-oxoazetidin-2-yl]methyl 4-methylbenzenesulfonate a41 (0.23 g, 0.9 mol, 1 eq), potassium carbonate (0.25 g, 1.8 mmol, 2 eq) and piperidine a14 (0.15 ml, 1.5 mmol, 1.6 eq) is refluxed in acetonitrile (5 ml) for 4 h. The reaction mixture is then concentrated and the residue is taken up in ether, filtered and concentrated to give 0.17 g of (4S)-4-(piperidin-1-ylmethyl)azetidin-2-one a42.

Provenance & Evidence