反应详情

A catalytic amount of concentrated sulfuric acid is added to a solution of 1-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylic acid a50 (3.7 g, 16.7 mmol, 1 eq) in methanol (100 ml) and the mixture is heated at reflux overnight. The solvent is then removed under vacuum, and the residue is dissolved into ethyl acetate. The organic layer is washed with a saturated solution of aqueous sodium hydrogenocarbonate, dried over magnesium sulfate and concentrated under vacuum to afford 3.5 g of methyl 1-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylate a51.

1. temperaturethe mixture is heated
2. temperatureat reflux overnight
3. customThe solvent is then removed under vacuum
4. dissolutionthe residue is dissolved into ethyl acetate
5. washThe organic layer is washed with a saturated solution of aqueous sodium hydrogenocarbonate
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated under vacuum