HCID 57550251, compound → HCID 57550255, compound

Participants

Reaction Steps

Palladium hydroxide on charcoal is added to a solution of (5S)-5-[(dibenzylamino)methyl]-1-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}pyrrolidin-2-one 112 (0.377 g, 0.74 mmol, 1 eq) in methanol (10 ml). The mixture is shaken overnight at room temperature under hydrogen atmosphere (45 psi). The mixture is filtered over celite and concentrated under vacuum. The residue is taken up in a mixture of methanol (10 ml) and 4 drops of aqueous 5 N hydrochloric acid. Palladium hydroxide on charcoal is added and the mixture is shaken again overnight at room temperature under hydrogen atmosphere (45 psi). The mixture is filtered over celite and concentrated under vacuum to give 0.245 g of (5S)-5-(aminomethyl)-1-{4-[3-(2-methylpyrrolidin-1-yl)propoxy]phenyl}pyrrolidin-2-one 113 as a yellow oil.

Provenance & Evidence