反应详情

温度

95 °C

Fuming sulfuric acid (25 mL, 30%) was added to 8.5 g (32 mmol) of 2-(4'isopropylbenzoyl)benzoic acid. The mixture was then heated to 95° C. for 1 h in a water bath. The resultant dark solution was poured cautiously over crushed ice to yield a beige solid which was extracted with chloroform. The chloroform layer was washed sever-al times with a dilute NaOH solution ≈10%), followed by a dilute HCl solution and finally with deionized water. The resultant yellow chloroform solution was dried with MgSO4, filtered and the chloroform was removed under vacuum to yield a yellow/orange solid. The product was recrystallized from heptane to yield a yellow product. (1.00 g, 113%), mp 53-54° C.

1. additionThe resultant dark solution was poured cautiously
2. customover crushed ice
3. customto yield a beige solid which
4. extractionwas extracted with chloroform
5. washThe chloroform layer was washed sever-al times with a dilute NaOH solution ≈10%),
6. dry with materialThe resultant yellow chloroform solution was dried with MgSO4
7. filtrationfiltered
8. customthe chloroform was removed under vacuum
9. customto yield a yellow/orange solid
10. customThe product was recrystallized from heptane
11. customto yield a yellow product