Sodium Thiosulfate → HCID 15949406, compound

Participants

Reaction Steps

A solution of 3-[(9-chloro-4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-N-(1-ethyl-1H-pyrazol-3-yl)-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}benzamide (300 mg, 0.57 mmol) in acetonitrile (10 mL) was treated with trimethylsilyl iodide (0.404 mL) and stirred at RT under argon for 3 hours. Sodium thiosulphate solution (30 mL) was added to quench the reaction and mixture was extracted with ethyl acetate (3×30 mL). The combined organic extracts were dried (MgSO4), filtered and evaporated to give a yellow oil. Purification by column chromatography on silica, eluting with 50-100% ethyl acetate in hexanes, gave the desired compound as a pale yellow solid (230 mg).

Provenance & Evidence