Ammonium formate → HCID 15949497, compound

Participants

Reaction Steps

To a solution of 3-[(1,1-dioxido-1-benzothien-5-yl)oxy]-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(1-methyl-1H-pyrazol-3-yl)benzamide (113 mg, 0.24 mmol) in ethanol (2.5 mL) was added ammonium formate (152 mg, 2.40 mmol) and 10% palladium on charcoal (25 mg) and the resultant mixture heated at 140° C. for 10 minutes in a microwave reactor. The catalyst was filtered and the residue reduced, taken up in DCM plus a little methanol and transferred to a silica cartridge, eluted with 0-3% methanol in DCM, to give the desired compound as a clear foam (65 mg).

Provenance & Evidence