Potassium hydroxy sulfite → HCID 57663196, compound

Participants

Reaction Steps

To a solution of 3-(1-benzothien-5-yloxy)-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(1-methyl-1H-pyrazol-3-yl)benzamide (178 mg, 0.41 mmol) in methanol (3 mL) at 0° C. was added dropwise a solution of oxone (752 mg, 1.22 mmol) in water (3 mL). The resultant cloudy slurry was allowed to warm to RT and stir for 16 hours. Water (20 mL) was added and the mixture extracted with DCM (3×20 mL). The combined extracts were dried (MgSO4), filtered and evaporated. The material was chromatographed on silica, eluting with 0-3% methanol in DCM, to give the desired compound as yellow oil (113 mg). m/z 470 (M+H)+

Provenance & Evidence