Trifluoroacetic acid → HCID 15949773, compound

Participants

Reaction Steps

Trifluoroacetic acid (1 mL) was added to 3-({2,2-dimethyl-3-[(methyloxy)methyl]-4-oxo-3,4-dihydro-2H-1,3-benzoxazin-7-yl}oxy)-N-(5-methylpyrazin-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide (54 mg, 0.1 mmol) and stirred at RT for 48 hours. DCM was added and the solvent removed in vacuo. Ethyl acetate (50 mL) was added and the mixture washed with water (50 mL), saturated sodium bicarbonate solution (50 mL), brine (50 mL), dried (MgSO4), and reduced in vacuo. The crude oil was chromatographed on silica, eluting with 0-2.5% methanol in ethyl acetate, to give the desired compound as a white foam (14 mg).

Provenance & Evidence