Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 548738Generated: October 30, 2026

3-Hydroxy-N-(5-methylpyrazin-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide → 3-[(9-Chloro-4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-N-(5-methylpyrazin-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide

https://huagongshe.com/reaction/548738

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Hydroxy-N-(5-methylpyrazin-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamideHCID 57663221—
Reactant9-chloro-8-fluoro-4-methyl-3,4-dihydro-1,4-benzoxazepin-5(2H)-oneHCID 57663226—
Product3-[(9-Chloro-4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-N-(5-methylpyrazin-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamideHCID 15949865—

Reaction Steps

The preparations of 3-hydroxy-N-(5-methylpyrazin-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide and 9-chloro-8-fluoro-4-methyl-3,4-dihydro-1,4-benzoxazepin-5(2H)-one were described earlier.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07943607B2
Source datasetuspto-grants-2011_05
ORD IDord-89de8236d0644b02aedfc6c50bd07958
Source noteuspto-grants-2011_05