Trifluoroacetic acid → HCID 178495717, compound

Participants

Reaction Steps

Trifluoroacetic acid (1 mL) was added to a solution of 1,1-dimethylethyl 3-{[(3-[(2-methyl-1,1-dioxido-3,4-dihydro-2H-5,1,2-benzoxathiazepin-7-yl)oxy]-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}phenyl)carbonyl]amino}-1H-pyrazole-1-carboxylate (50 mg, 0.08 mmol) in DCM (8 mL) and stirred at RT for 2 hours. The solvent was removed in vacuo and DCM (20 mL). The mixture was washed with water (20 mL), a saturated solution of sodium bicarbonate (20 mL), brine (20 mL), dried (MgSO4), filtered and reduced in vacuo to give the desired compound as a white foam (31 mg). 1H NMR δ (CDCl3): 1.33 (d, 3H), 2.80 (s, 3H), 3.40 (s, 3H), 3.51-3.61 (m, 2H), 3.71-3.73 (m, 2H), 4.17-4.22 (m, 2H), 4.57-4.65 (m, 1H), 6.72-6.74 (m, 1H), 6.79-6.84 (m, 2H), 6.86 (s, 1H), 7.20 (s, 1H), 7.41 (s, 1H), 7.49 (s, 1H), 7.78 (d, 1H), 9.59 (s, 1H), 10.20 (s, 1H); m/z 503 (M+H)+

Provenance & Evidence