tert-Butyl 3-amino-1H-pyrazole-1-carboxylate → HCID 178495716, compound

HRID 548772Notes

Reaction equation

HRID 548772 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][N:4](C(OC(C)(C)C)=O)[N:3]=1.[O:14]=[S:15]1(=[O:42])[C:21]2[CH:22]=[CH:23][C:24]([O:26][C:27]3[CH:28]=[C:29]([CH:33]=[C:34]([O:36][C@@H:37]([CH3:41])[CH2:38][O:39][CH3:40])[CH:35]=3)[C:30](O)=[O:31])=[CH:25][C:20]=2[O:19][CH2:18][CH2:17][CH2:16]1>>[O:42]=[S:15]1(=[O:14])[C:21]2[CH:22]=[CH:23][C:24]([O:26][C:27]3[CH:28]=[C:29]([CH:33]=[C:34]([O:36][C@@H:37]([CH3:41])[CH2:38][O:39][CH3:40])[CH:35]=3)[C:30]([NH:1][C:2]3[CH:6]=[CH:5][NH:4][N:3]=3)=[O:31])=[CH:25][C:20]=2[O:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 51358380tert-Butyl 3-amino-1H-pyrazole-1-carboxylateHCID 576631923-[(5,5-dioxido-3,4-dihydro-2H-1,5-benzoxathiepin-8-yl)oxy]-5-{[(s)-1-methyl-2-(methyloxy)ethyl]oxy}benzoic acid

Product 1

HCID 178495716HCID 178495716, compound

Procedure

The preparation of 1,1-dimethylethyl 3-amino-1H-pyrazole-1-carboxylate was described earlier. The preparation of 3-[(5,5-dioxido-3,4-dihydro-2H-1,5-benzoxathiepin-8-yl)oxy]-5-{[(s)-1-methyl-2-(methyloxy)ethyl]oxy}benzoic acid is described below.

Sources & evidence

ORD record
ord-6b2bf230ec6948afbb90dc45d3a59b60
Source dataset
uspto-grants-2011_05
Patent number
US07943607B2

Reaction notes

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