Water → 2-Methyl-2-propoxypropan-1-ol

HRID 548779Notes

Reaction equation

HRID 548779 reaction equation
Br[C:2]([CH3:13])([CH3:12])[CH:3](OCCC)OCCC.C([CH:17]([CH:19]([C:21]([O-:23])=O)O)O)(O)=O.[K+].[OH2:25]>>[CH3:3][C:2]([O:23][CH2:21][CH2:19][CH3:17])([CH3:13])[CH2:12][OH:25]

Participants

4

Reactant 3

HCID 962WaterHCID 23666342Potassium hydrogentartrateHCID 866231192-Bromo-2-methyl-1,1-dipropoxypropane

Product 1

HCID 867613132-Methyl-2-propoxypropan-1-ol

Procedure

2-Methyl-2-propoxypropanol was prepared according to a modified method described in U.S. Pat. No. 3,652,579. A slurry consisting of 2-bromo-2-methyl-1,1-dipropoxypropane obtained from Example 2(a) (6.5 g, 0.026 mol), potassium hydrogen tartrate (4.8 g, 0.026 mol) in water (75 mL) was heated at reflux for 7 h. A distillation set-up was mounted and the liquid that was distilled between 82-90° C. was collected. The organic phase was separated. The obtained crude product (1.9 g, 56%) was used without further purification.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 7 h
  3. distillationthe liquid that was distilled between 82-90° C.
  4. customwas collected
  5. customThe organic phase was separated

Sources & evidence

ORD record
ord-50942864e1684b1a93b2b7bb04f238eb
Source dataset
uspto-grants-2011_05
Patent number
US07943625B2

Reaction notes

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