Ethylenediamine → N-(2-Aminoethyl)-6-(2-fluoro-4-iodophenylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Ethylenediamine	HCID 3301	—
Reactant	Phenyl 6-(2-fluoro-4-iodophenylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate	HCID 59259226	—
Product	N-(2-Aminoethyl)-6-(2-fluoro-4-iodophenylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide	HCID 25109090	—

Reaction Steps

Example 42 was synthesized following a similar procedure described in the synthesis of Example 5 by reaction of compound 2A and ethane-1,2-diamine. 1H NMR (400 MHz, CDCl3) δ 7.67 (d, J=8.0 Hz, 1H) 7.62 (d, J=8.0 Hz, 1H) 7.01 (t, J=8.0 Hz, 1H) 3.63 (t, J=4.0 Hz, 2H) 3.27 (s, 3H) 3.15 (t, J=4.0 Hz, 2H) 3.11 (s, 3H). [M+H] calc'd for C15H17FIN5O3, 462. found, 462.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07943626B2
Source dataset	uspto-grants-2011_05
ORD ID	ord-b611985c759d47b89f91bf8c2dacccaa
Source note	uspto-grants-2011_05