HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,6-Dichloropyridazine → 3-Iodo-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,6-Dichloropyridazine | HCID 67331 | — |
| Reactant | (5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol | HCID 2776149 | — |
| Reactant | 3-Chloro-6-iodopyridazine | HCID 15418839 | — |
| Product | 3-Iodo-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine | HCID 86630894 | 81% |
Reaction Steps
As described for example 1, (5-methyl-3-phenyl-isoxazol-4-yl)-methanol (10.0 g, 53 mmol) was converted using 3-chloro-6-iodopyridazine (Goodman, A. J.; Stanforth, S. P.; Tarbit, B. Tetrahedron 1999, 55, 15067) instead of 3,6-dichloropyridazine to the title compound (16.9 g, 81%) which was contaminated with ca. 20% of 3-chloro-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine. The product was obtained as an off white solid. MS: m/e=394.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943619B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-07a34e480e6a4df29fc721f2a66fdd31 |
| Source note | uspto-grants-2011_05 |