Cyclobutanecarbonyl chloride → HCID 42629773, compound

HRID 548824Notes

Reaction equation

HRID 548824 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[N:20]=[N:19][C:18]([NH2:21])=[CH:17][CH:16]=1.[CH:22]1([C:26](Cl)=[O:27])[CH2:25][CH2:24][CH2:23]1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[CH2:13][O:14][C:15]1[N:20]=[N:19][C:18]([NH:21][C:26]([CH:22]2[CH2:25][CH2:24][CH2:23]2)=[O:27])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 78705Cyclobutanecarbonyl chlorideHCID 426297716-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-ylamine

Product 1

HCID 42629773HCID 42629773, compoundYield 64%

Procedure

As described for example 18, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-ylamine (200 mg, 0.7 mmol) was converted, using cyclobutanecarbonyl chloride instead of methoxyacetyl chloride, to the title compound (165 mg, 64%) which was obtained as a white solid. MS: m/e=365.4 [M+H]+.

Sources & evidence

ORD record
ord-093f47daf9e54b0e8fea1695049d0bca
Source dataset
uspto-grants-2011_05
Patent number
US07943619B2

Reaction notes

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