4-Methylbenzoyl Chloride → HCID 67157369, compound

HRID 548833Notes

Reaction equation

HRID 548833 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[N:20]=[N:19][C:18]([NH2:21])=[CH:17][CH:16]=1.[C:22]1([CH3:31])[CH:27]=[CH:26][C:25]([C:28](Cl)=[O:29])=[CH:24][CH:23]=1>>[CH3:31][C:22]1[CH:27]=[CH:26][C:25]([C:28]([NH:21][C:18]2[N:19]=[N:20][C:15]([O:14][CH2:13][C:3]3[C:4]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=4)=[N:5][O:6][C:2]=3[CH3:1])=[CH:16][CH:17]=2)=[O:29])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 134054-Methylbenzoyl ChlorideHCID 426297716-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-ylamine

Product 1

HCID 67157369HCID 67157369, compoundYield 80%

Procedure

As described for example 18, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-ylamine (280 mg, 1 mmol) was converted, using p-toluoyl chloride instead of methoxyacetyl chloride, to the title compound (320 mg, 80%) which was obtained as a white solid. MS: m/e=401.3 [M+H]−.

Sources & evidence

ORD record
ord-d72db2a834eb430b9e03fdcc28ff992d
Source dataset
uspto-grants-2011_05
Patent number
US07943619B2

Reaction notes

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