Isoxazole-5-carbonyl chloride → HCID 42629892, compound

HRID 548835Notes

Reaction equation

HRID 548835 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[N:20]=[N:19][C:18]([NH2:21])=[CH:17][CH:16]=1.[O:22]1[C:26]([C:27](Cl)=[O:28])=[CH:25][CH:24]=[N:23]1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[CH2:13][O:14][C:15]1[N:20]=[N:19][C:18]([NH:21][C:27]([C:26]2[O:22][N:23]=[CH:24][CH:25]=2)=[O:28])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 2736707Isoxazole-5-carbonyl chlorideHCID 426297716-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-ylamine

Product 1

HCID 42629892HCID 42629892, compoundYield 77%

Procedure

As described for example 18, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazin-3-ylamine (280 mg, 1 mmol) was converted, using isoxazole-5-carbonyl chloride instead of methoxyacetyl chloride, to the title compound (290 mg, 77%) which was obtained as a white solid. MS: m/e=378.2 [M+H]+.

Sources & evidence

ORD record
ord-849ccd156b8a48e2a9b651a5f75cf771
Source dataset
uspto-grants-2011_05
Patent number
US07943619B2

Reaction notes

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