4-Aminotetrahydropyran → 4-Methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid (tetrahydro-pyran-4-yl)-amide

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Reaction Steps

As described for example 11b, 4-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid (200 mg, 0.61 mmol), instead of 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid, was converted, using 4-amino-tetrahydropyran instead of thiomorpholine 1,1-dioxide, to the title compound (SiO2, heptane:ethyl acetate=100:0 to 60:40, 156 mg, 62%) which was obtained as a white solid. MS: m/e=409.3 [M+H]−.

Provenance & Evidence