Isopropylamine → 4-Methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid isopropylamide
Reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[C:11]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[N:12][O:13][C:14]=2[CH3:15])[N:5]=[N:4][C:3]=1[C:22]([OH:24])=O.[CH:25]([NH2:28])([CH3:27])[CH3:26]>>[CH:25]([NH:28][C:22]([C:3]1[N:4]=[N:5][C:6]([O:8][CH2:9][C:10]2[C:11]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[N:12][O:13][C:14]=2[CH3:15])=[CH:7][C:2]=1[CH3:1])=[O:24])([CH3:27])[CH3:26]Participants
3
Procedure
As described for example 44, 4-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid (200 mg, 0.61 mmol) was converted, using isopropylamine instead of 4-amino-tetrahydropyran, to the title compound (SiO2, heptane:ethyl acetate=100:0 to 60:40, 90 mg, 40%) which was obtained as a white solid. MS: m/e=367.2 [M+H]+.
Sources & evidence
- ORD record
- ord-b218936610a047e895c884b86b5ea469
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07943619B2
Reaction notes
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