Ethanol → HCID 42630253, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-chloro-6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridazine (4.1 g, 13 mmol) in ethanol (65 mL) was added sodium carbonate (1.37 g, 13 mmol), 1,1′-bis(diphenylphosphino)ferrocene (716 mg, 1.3 mmol) and palladium(II) acetate (290 mg, 1.3 mmol). The resulting mixture was heated at 50° C. overnight under a carbon monoxide atmosphere. After cooling to room temperature the mixture was diluted with ethanol (100 mL), filtered through Celite® and concentrated. Purification by chromatography (SiO2, heptane:ethyl acetate=100:0 to 1:1) afforded the title compound (3.2 g, 70%) as an off white solid. MS: m/e=358.0 [M+H]−.

Provenance & Evidence