Ethylamine → HCID 42630250, compound

HRID 548854Notes

Reaction equation

C(O[C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=[O:5])C.[CH2:27]([NH2:29])[CH3:28]>>[CH2:27]([NH:29][C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=[O:5])[CH3:28]

Participants

Reactant 2

HCID 6341Ethylamine

HCID 42630253HCID 42630253, compound

Product 1

HCID 42630250HCID 42630250, compoundYield 61%

Procedure

As described for example 50, 6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester (143 mg, 0.4 mmol) was converted, using ethylamine instead of methylamine, to the title compound (87 mg, 61%) which was obtained as a white solid. MS: m/e=357.3 [M+H]+.

Sources & evidence

ORD record: ord-de7aa84e19a0476f9a1bf36a394c4341
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07943619B2

Reaction notes

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