Ethanamine, 2,2,2-trifluoro- → HCID 67158140, compound

HRID 548870Notes

Reaction equation

C(O[C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=[O:5])C.[F:26][C:27]([F:31])([F:30])[CH2:28][NH2:29]>>[F:26][C:27]([F:31])([F:30])[CH2:28][NH:29][C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:21]=[CH:22][N:23]=[CH:24][CH:25]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=[O:5]

Participants

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-

HCID 67157617HCID 67157617, compound

Product 1

HCID 67158140HCID 67158140, compoundYield 66%

Procedure

As described for example 67e, 6-(5-methyl-3-pyridin-4-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid ethyl ester (100 mg, 0.29 mmol) was converted, using 2,2,2-trifluoroethylamine instead of aminomethylcyclopropane, to the title compound (76 mg, 66%) which was obtained as a white solid. MS: m/e=394.1 [M+H]+.

Sources & evidence

ORD record: ord-2784769bd4e646e399b718c9e15d29d0
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07943619B2

Reaction notes

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