Methanol → 6-[(5-Methyl-3-phenyl-isoxazol-4-ylmethyl)-amino]-pyridazine-3-carboxylic acid methyl ester

Participants

Reaction Conditions

Reaction Steps

To a solution of (6-iodo-pyridazine-3-yl)-(5-methyl-3-phenyl-isoxazol-4ylmethyl)-amine (1.0 g, 2.6 mmol) in methanol (3 mL) was added sodium carbonate (270 mg, 2.6 mmol), 1,1′-bis(diphenylphosphino)ferrocene (141 mg, 0.26 mmol) and palladium(II) acetate (57 mg, 0.26 mmol). The resulting mixture was heated at 50° C. for 16 h under a carbon monoxide atmosphere. After cooling to room temperature it was filtered through Celite® and concentrated. Purification by chromatography (SiO2, heptane:ethyl acetate=100:0 to 20:80) afforded the title compound (720 mg, 87%) as a light brown solid. MS: m/e=325.3 [M+H]+.

Provenance & Evidence