Ethanamine, 2,2,2-trifluoro- → 6-{[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-amino}-pyridazine-3-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

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Reaction Steps

As described for example 81, 6-{[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-amino}-pyridazine-3-carboxylic acid ethyl ester (89 mg, 0.25 mmol) was converted, using 2,2,2-trifluoroethylamine instead of aminomethylcyclopropane, to the title compound (91 mg, 89%) which was obtained as an off white solid. MS: m/e=410.3 [M+H]+.

Provenance & Evidence