HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminotetrahydropyran → 6-{[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-amino}-pyridazine-3-carboxylic acid (tetrahydro-pyran-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminotetrahydropyran | HCID 419223 | — |
| Reactant | 6-{[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-amino}-pyridazine-3-carboxylic acid ethyl ester | HCID 67157863 | — |
| Product | 6-{[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-amino}-pyridazine-3-carboxylic acid (tetrahydro-pyran-4-yl)-amide | HCID 67158200 | 62% |
Reaction Steps
As described for example 81, 6-{[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-amino}-pyridazine-3-carboxylic acid ethyl ester (89 mg, 0.25 mmol) was converted, using 4-aminotetrahydropyran instead of aminomethylcyclopropane, to the title compound (64 mg, 62%) which was obtained as a white foam. MS: m/e=412.5 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943619B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-a2da2416ae0448b4ab6ef092e6729afd |
| Source note | uspto-grants-2011_05 |