Ethanolamine → HCID 42630624, compound

HRID 548895Notes

Reaction equation

C(O[C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=[O:5])C.[NH2:26][CH2:27][CH2:28][OH:29]>>[OH:29][CH2:28][CH2:27][NH:26][C:4]([C:6]1[N:7]=[N:8][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:21]=[CH:22][N:23]=[CH:24][CH:25]=3)=[N:16][O:17][C:18]=2[CH3:19])=[CH:10][CH:11]=1)=[O:5]

Participants

Reactant 2

HCID 700Ethanolamine

HCID 67157617HCID 67157617, compound

Product 1

HCID 42630624HCID 42630624, compoundYield 23%

Procedure

As described for example 69, 6-(5-methyl-3-pyridin-4-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid ethyl ester (100 mg, 0.29 mmol) was converted, using 2-aminoethanol instead of isopropylamine, to the title compound (24 mg, 23%) which was obtained as a light yellow solid. MS: m/e=356.3 [M+H]+.

Sources & evidence

ORD record: ord-3d2b32f3c5ac4ac3ba7da870e6da8d68
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07943619B2

Reaction notes

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