反应详情

As described for example 67e, 6-{[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-amino}-pyridazine-3-carboxylic acid ethyl ester (106 mg, 0.3 mmol) was converted, instead of 6-[(5-methyl-3-phenyl-isoxazol-4-ylmethyl)-amino]-pyridazine-3-carboxylic acid methyl ester, using cyclopropylamine instead of aminomethylcyclopropane, to the title compound (83 mg, 75%) which was obtained as a white solid. MS: m/e=368.1 [M+H]+.