反应详情

As described for example 112a, 6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid ethyl ester (693 mg, 2.12 mmol) was converted, instead of 5-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-pyrazine-2-carboxylic acid methyl ester, to the title compound (544 mg, 86%) which was obtained as a grey solid. MS: m/e=297.5 [M−H]−.