HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester → 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester | HCID 66643614 | — |
| Reactant | 5-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-pyrazine-2-carboxylic acid methyl ester | HCID 67157839 | — |
| Product | 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid | HCID 67157810 | 67% |
Reaction Steps
As described for example 112a, 3-(5-fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester (1.0 g, 4.23 mmol) was converted, instead of 5-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-pyrazine-2-carboxylic acid methyl ester, to the title compound (587 mg, 67%) which was obtained as a dark brown solid. MS: m/e=207.1 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943619B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-973ed1ab6efa4c2fa32060bf88254aca |
| Source note | uspto-grants-2011_05 |