HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid → [3-(5-Fluoro-pyridin-2-yl)-isoxazol-4-yl]-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid | HCID 67157810 | — |
| Reactant | 5-Methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid | HCID 67157819 | — |
| Product | [3-(5-Fluoro-pyridin-2-yl)-isoxazol-4-yl]-methanol | HCID 66643813 | 70% |
Reaction Steps
As described for example 114g, 3-(5-fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid (562 mg, 2.7 mmol) was converted, instead of 5-methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid, to the title compound (367 mg, 70%) which was obtained as an off white solid. MS: m/e=195.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943619B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-5accd98b26074863ba46461d5544b15a |
| Source note | uspto-grants-2011_05 |