反应详情

As described for example 112a, 6-[3-(5-fluoro-pyridin-2-yl)-isoxazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester (405 mg, 1.18 mmol) was converted, instead of 5-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-pyrazine-2-carboxylic acid methyl ester, to the title compound (349 mg, 94%) which was obtained as an off white solid. MS: m/e=315.1 [M−H]−.