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Hydrochloric Acid → 5-Bromo-n4-cyclopropyl-n2-(3-methylsulphanylphenyl)pyrimidine-2,4-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Benzenamine, 3-(methylthio)- | HCID 15693 | — |
| 反応物 | 5-bromo-2-chloro-N-cyclopropylpyrimidin-4-amine | HCID 58459934 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 5-Bromo-n4-cyclopropyl-n2-(3-methylsulphanylphenyl)pyrimidine-2,4-diamine | HCID 59683148 | — |
反応手順
In analogy to compound 2.1, 0.58 g (2.33 mmol) of (5-bromo-2-chloropyrimidin-4-yl)-cyclopropylamine is reacted with 0.296 g (2.12 mmol) of 3-methylsulphanyl-phenylamine in 7.0 ml of acetonitrile in the presence of 0.53 mol of a 4 molar solution of hydrogen chloride in dioxane, and 0.67 ml of water. 0.6 g (73% of theory) of the product is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07943629B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-bf3dfe5ac7c3406e999f7f90533ee1b7 |
| 出典メモ | uspto-grants-2011_05 |