Water → HCID 22477355, compound

Participants

Reaction Steps

A suspension of 3-(5H-pyrrolo[2,3-b]pyrazin-6-yl)-benzaldehyde [0.4 g, Example 9(a)] in ethanol (50 mL) was treated with sodium borohydride (200 mg). The mixture was allowed to stir at ambient temperature for 1 hour then treated with water (10 mL) and then evaporated. The residual solid was triturated with water (50 mL) to give a pale yellow solid which was washed with water and then recrystallised from methanol to yield the title compound (0.35 g) as a yellow crystalline solid, m.p. 225-226° C. [Elemental analysis:— C, 68.72; H, 4.73; N, 18.44%. Calculated for C13H11N3O:— C, 69.32; H, 4.92; N, 18.65%].

Provenance & Evidence