反应详情

A solution of 2-(5-methoxy-1-methyl-1H-indol-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine [1.45 g, Reference Example 13(b)] in methanol (100 mL) was treated with potassium hydroxide (5N, 15 mL) then heated at reflux for 2 hours. The reaction mixture was cooled then evaporated. The residue was treated with water (150 mL) and the resulting solid was filtered then dried to give the title compound (0.75 g) as a tan solid, m.p. 226-227° C. MS: 278 (MH+).

1. temperaturethen heated
2. temperatureat reflux for 2 hours
3. temperatureThe reaction mixture was cooled
4. customthen evaporated
5. additionThe residue was treated with water (150 mL)
6. filtrationthe resulting solid was filtered
7. customthen dried