HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → (6-Chloro(3-pyridyl)methyl] (2-chloroethylamino}ethanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (6-Chloro(3-pyridyl)methyl](2-hydroxyethylamino}ethanenitrile | HCID 86624867 | — |
| Catalyst | Pyridine | HCID 1049 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (6-Chloro(3-pyridyl)methyl] (2-chloroethylamino}ethanenitrile | HCID 86624866 | — |
Reaction Steps
This compound was prepared in a manner analogous to that set forth in Step C of Example 1, using 5.7 grams (0.0255 mole) of 2-{[(6-chloro(3-pyridyl)methyl](2-hydroxyethylamino}ethanenitrile 3.2 grams (0.0268 mole) of thionyl chloride and one drop (catalyst) of pyridine in 50 mL of chloroform. The yield of the subject compound was 6.0 grams. The NMR spectrum was consistent with the proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943642B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-58378f85ee644cb2850e5714cffc67a6 |
| Source note | uspto-grants-2011_05 |