Cyclobutanone → HCID 67157619, compound

Participants

Reaction Steps

4-[(4-Amino-2-ethyl-2H-pyrazolo[3,4-c]quinolin-1-yl)methyl]piperidin-4-ol was prepared according to the method of Example 1 Part F using di(tert-butyl)2-ethyl-1-methyl-2H-pyrazolo[3,4-c]quinolin-4-ylimidodicarbonate in lieu of di(tert-butyl)1-methyl-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-ylimidodicarbonate and tert-butyl 4-oxopiperidine-1-carboxylate in lieu of cyclobutanone. The crude product was recrystallized from acetonitrile to provide 1.09 g of 1-[(4-amino-2-ethyl-2H-pyrazolo[3,4-c]quinolin-1-yl)methyl]piperidin-4-ol as an off-white solid.

Provenance & Evidence